GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs1577917 | 1 | rs6454513 | chr6:86720049 | SNHG5 | chr6:86386726-86388451:- | 0.57 | 7.62 | 1.9E-11 | Response to antipsychotic treatment |
| THYM | cis | rs6911965 | 1 | rs6456617 | chr6:24480769 | GPLD1 | chr6:24428405-24489850:- | 0.56 | 5.18 | 1.24E-6 | Hematological and biochemical traits |
| THYM | cis | rs9369898 | 1 | rs6458685 | chr6:49379536 | CENPQ | chr6:49431096-49460820:+ | -0.3 | -5.65 | 1.67E-7 | Homocysteine levels |
| THYM | cis | rs9369898 | 1 | rs6458688 | chr6:49406056 | CENPQ | chr6:49431096-49460820:+ | -0.29 | -5.57 | 2.36E-7 | Homocysteine levels |
| THYM | cis | rs9473555 | 1 | rs6458690 | chr6:49411619 | CENPQ | chr6:49431096-49460820:+ | -0.24 | -4.48 | 2.1E-5 | Folate pathway vitamin levels |
| THYM | cis | rs9473555 | 1 | rs6458694 | chr6:49445306 | CENPQ | chr6:49431096-49460820:+ | -0.24 | -4.35 | 3.42E-5 | Folate pathway vitamin levels |
| THYM | cis | rs9473555 | 1 | rs6458694 | chr6:49445306 | MUT | chr6:49398994-49431031:- | 0.28 | 4.29 | 4.25E-5 | Folate pathway vitamin levels |
| THYM | cis | rs2243480 | 1 | rs6460260 | chr7:65215455 | CCT6P1 | chr7:65216092-65228661:+ | -0.76 | -5.86 | 6.67E-8 | Diabetic kidney disease |
| THYM | cis | rs2243480 | 1 | rs6460261 | chr7:65215580 | CCT6P1 | chr7:65216092-65228661:+ | -0.76 | -5.86 | 6.67E-8 | Diabetic kidney disease |
| THYM | cis | rs2243480 | 1 | rs6460274 | chr7:65628484 | CCT6P1 | chr7:65216092-65228661:+ | -0.65 | -5.41 | 4.64E-7 | Diabetic kidney disease |
| THYM | cis | rs3091242 | 1 | rs646867 | chr1:25709258 | RHCE | chr1:25688741-25756683:- | 0.42 | 5.05 | 2.09E-6 | Erythrocyte sedimentation rate |
| THYM | cis | rs3091242 | 1 | rs646867 | chr1:25709258 | RHD | chr1:25598981-25656935:+ | -0.46 | -4.29 | 4.26E-5 | Erythrocyte sedimentation rate |
| THYM | cis | rs6477694 | 1 | rs6477694 | chr9:111932342 | AKAP2 | chr9:112810976-112934789:+ | -0.2 | -4.42 | 2.59E-5 | Body mass index |
| THYM | cis | rs881375 | 1 | rs6478484 | chr9:123652380 | LOC253039 | chr9:123605320-123616644:+ | -0.62 | -5.56 | 2.51E-7 | Rheumatoid arthritis |
| THYM | cis | rs881375 | 1 | rs6478486 | chr9:123655329 | LOC253039 | chr9:123605320-123616644:+ | -0.62 | -5.56 | 2.51E-7 | Rheumatoid arthritis |